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In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical ""auto-mail"" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.

Alchemy: the mystical power to alter the natural world, somewhere between magic, art and science. When two brothers, Edward and Alphonse Elric, dabbled in these powers to grant their dearest wish, one of them lost an arm and a leg...and the other became nothing but a soul locked into a body of living iron. Now they are agents of the government, slaves of the military-alchemical complex, using their unique powers to obey their orders...even to kill. But their powers aren't unique. The world crawls with evil alchemists. And in pursuit of the ultimate alchemical treasure, the Philosopher's Stone, their enemies are even more ruthless than they are...