Dana Claire Simpson grew up in Gig Harbor, Washington, drawing the entire time. She eventually graduated from The Evergreen State College, despite having spent all her time drawing, and not always for credit.

From 1998 to 2008, she drew the internet comic strip Ozy and Millie. After winning the Amazon-sponsored Comic Strip Superstar Contest in 2009, Andrews McMeel Syndication signed her to a development deal for Heavenly Nostrils, which was later renamed Phoebe and Her Unicorn.

She currently lives in Santa Barbara, California, with her tech genius spouse and her fairly stupid cat.